Arber lab
Our overall goal is to develop novel targeted immunotherapies for patients with hematologic malignancies. The group develops adoptive T cell therapies with native or engineered receptors and evaluates combinatorial strategies. The objective is to efficiently target tumor cells, mitigate immunosuppressive tumor microenvironment factors, favor tumor-targeted migration and longevity of transferred T cells, control potential toxicities, identify novel personalized targets, and move developments to the clinic. ...
Research projects
Please check back later to discover our ongoing projects.
Latest publications
Two to tango: engineered T cells against AML.
Arber C
Blood – 2024 Feb 8
Hematopoietic cell transplantation and cellular therapies in Switzerland. Evolution over 25 years.
Passweg JR, Baldomero H, Ansari M, Wannesson L, Halter JP
Hematological oncology – 2023 Dec 6
Reductive carboxylation epigenetically instructs T cell differentiation.
Jaccard A, Wyss T, Maldonado-Pérez N, (...), Romero P, Ho PC, Wenes M
Nature – 2023 Sep 20
Computational design of dynamic receptor-peptide signaling complexes applied to chemotaxis.
Jefferson RE, Oggier A, Füglistaler A, (...), Villarreal AR, Arber C, Barth P
Nature communications – 2023 May 19
Both APRIL and antibody-fragment-based CAR T cells for myeloma induce BCMA downmodulation by trogocytosis and internalization.
Camviel N, Wolf B, Croce G, (...), Gfeller D, Zoete V, Arber C
Journal for immunotherapy of cancer – 2022 Nov 3
Rapid Generation of TCR and CD8αβ Transgenic Virus Specific T Cells for Immunotherapy of Leukemia.
Bajwa G, Arber C
Frontiers in immunology – 2022 Apr 29
Team
Caroline Arber Barth
Associate Professor, Department of Oncology UNIL & CHUV, Ludwig adjunct scientist, Ludwig Institute for Cancer Research Lausanne
caroline.arber@unil.chOther members
Selected Publications
Reductive carboxylation epigenetically instructs T cell differentiation.
Jaccard A, Wyss T, Maldonado-Pérez N, (...), Romero P, Ho PC, Wenes M
Nature – 2023 Sep 20
Off-the-Shelf Allogeneic T Cell Therapies for Cancer: Opportunities and Challenges Using Naturally Occurring
Perez C, Gruber I, Arber C
Frontiers in immunology – 2020 Nov 11
Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4+ T cells.
Rath JA, Bajwa G, Carreres B, (...), Brenner MK, Gfeller D, Arber C
Science advances – 2020 Jul 3
Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy.
Rath JA, Arber C
Cells – 2020 Jun 18
c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals.
Nishimura CD, Brenner DA, Mukherjee M, (...), Brenner MK, Lin CY, Arber C
Blood – 2017 Oct 27
Reprogramming cellular functions with engineered membrane proteins.
Arber C, Young M, Barth P
Current opinion in biotechnology – 2017 Jul 11
CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia.
Bonifant CL, Szoor A, Torres D, (...), Song XT, Redell M, Gottschalk S
Molecular therapy : the journal of the American Society of Gene Therapy – 2016 Jun 6
Survivin-specific T cell receptor targets tumor but not T cells.
Arber C, Feng X, Abhyankar H, (...), Barth P, Dotti G, Savoldo B
The Journal of clinical investigation – 2014 Nov 21
Mouse models in bone marrow transplantation and adoptive cellular therapy.
Arber C, Brenner MK, Reddy P
Seminars in hematology – 2013 Jun 11
The immunogenicity of virus-derived 2A sequences in immunocompetent individuals.
Arber C, Abhyankar H, Heslop HE, (...), Liu H, Dotti G, Savoldo B
Gene therapy – 2013 May 23
Graft source determines human hematopoietic progenitor distribution pattern within the CD34(+) compartment.
Arber C, Halter J, Stern M, (...), Rovó A, Gratwohl A, Tichelli A
Bone marrow transplantation – 2010 Aug 16
Black hole in the lung.
Cantoni N, Weisser M, Frei R, Lardinois D, Arber C
Bone marrow transplantation – 2010 Mar 29
Platelet refractoriness due to combined anti-HLA and anti-HPA-5a alloantibodies: clinical management during myeloablative allogeneic HSCT and development of a quantitative MAIPA assay.
Arber C, Bertrand G, Halter J, (...), Boehlen F, Kaplan C, Gratwohl A
British journal of haematology – 2007 Oct
Septic polyarthritis with Ureaplasma urealyticum in a patient with prolonged agammaglobulinemia and B-cell aplasia after allogeneic HSCT and rituximab pretreatment.
Arber C, Buser A, Heim D, (...), Tichelli A, Passweg J, Gratwohl A
Bone marrow transplantation – 2007 Jul 9
Cyclosporine-responsive thrombocytopenia in a patient with chloramphenicol-associated myelodysplastic syndrome.
Arber C, Buser A, Heim D, (...), Gratwohl A, Tichelli A, Passweg JR
European journal of haematology – 2006 Mar
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