Ciriello lab

Our laboratory integrates algorithmic design, data science, and molecular biology approaches to address relevant questions in cancer biology and therapeutics. We explore single and combinations of genetic and epigenetic alterations that emerge and are selected during cancer evolution, to understand cancer driving mechanisms and inform precision medicine approaches. Our group is embedded within the Department of Computational Biology of the University of Lausanne, and a member of the Swiss Cancer Center Leman (SCCL), the Swiss Institute of Bioinformatics (SIB), the Center of Precision Oncology of the CHUV, and the Swiss Institute for Experimental Cancer Research (ISREC). ...

Selected Publications

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL.

Antoszewski M, Fournier N, Ruiz Buendía GA, (...), Weng AP, Koch U, Radtke F

Blood – 2022 Apr 21

Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING.

Bruand M, Barras D, Mina M, (...), Martinon F, Dangaj Laniti D, Coukos G

Cell reports – 2021 Jul 20

The many faces of cancer evolution.

Ciriello G, Magnani L

iScience – 2021 May 11

Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes.

Liu Y, Nanni L, Sungalee S, (...), Ceri S, Oricchio E, Ciriello G

Nature communications – 2021 May 10

Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci.

Sungalee S, Liu Y, Lambuta RA, (...), Roulland S, Ciriello G, Oricchio E

Nature genetics – 2021 May 10

Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression.

Saghafinia S, Homicsko K, Di Domenico A, (...), Ciriello G, Michael IP, Hanahan D

Cancer discovery – 2021 Apr 28

Discovering functional evolutionary dependencies in human cancers.

Mina M, Iyer A, Tavernari D, Raynaud F, Ciriello G

Nature genetics – 2020 Sep 28

Dynamic Emergence of Observed and Hidden Intra-tumor Heterogeneity.

Raynaud F, Mina M, Ciriello G

iScience – 2019 Oct 10

EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains.

Donaldson-Collier MC, Sungalee S, Zufferey M, (...), Manley S, Ciriello G, Oricchio E

Nature genetics – 2019 Jan 28

Comparison of computational methods for the identification of topologically associating domains.

Zufferey M, Tavernari D, Oricchio E, Ciriello G

Genome biology – 2018 Dec 10

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors.

Saghafinia S, Mina M, Riggi N, Hanahan D, Ciriello G

Cell reports – 2018 Oct 23

Pan-cancer inference of intra-tumor heterogeneity reveals associations with different forms of genomic instability.

Raynaud F, Mina M, Tavernari D, Ciriello G

PLoS genetics – 2018 Sep 13

Oncogenic Signaling Pathways in The Cancer Genome Atlas.

Sanchez-Vega F, Mina M, Armenia J, (...), Ciriello G, Sander C, Schultz N

Cell – 2018 Apr 5

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies.

Mina M, Raynaud F, Tavernari D, (...), Schultz N, Oricchio E, Ciriello G

Cancer cell – 2017 Jul 27

Emerging landscape of oncogenic signatures across human cancers.

Ciriello G, Miller ML, Aksoy BA, (...), Senbabaoglu Y, Schultz N, Sander C

Nature genetics – 2013 Oct

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