Ciriello lab
Our laboratory integrates algorithmic design, data science, and molecular biology approaches to address relevant questions in cancer biology and therapeutics. We explore single and combinations of genetic and epigenetic alterations that emerge and are selected during cancer evolution, to understand cancer driving mechanisms and inform precision medicine approaches. Our group is embedded within the Department of Computational Biology of the University of Lausanne, and a member of the Swiss Cancer Center Leman (SCCL), the Swiss Institute of Bioinformatics (SIB), the Center of Precision Oncology of the CHUV, and the Swiss Institute for Experimental Cancer Research (ISREC). ...
Research projects
Please check back later to discover our ongoing projects.
Latest publications
Decoding the Clinical and Molecular Signatures of EGFR Common, Compound, and Uncommon Mutations in Non-Small Cell Lung Cancer.
Tavernari D, Borgeaud M, Liu X, (...), Le X, Ciriello G, Addeo A
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer – 2024 Dec 16
Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening.
Santamaria-Martínez A, Epiney J, Srivastava D, (...), Ciriello G, Cairoli A, Oricchio E
Nature communications – 2024 Dec 9
Cancer Evolution: A Multifaceted Affair.
Ciriello G, Magnani L, Aitken SJ, (...), Tonon G, Vanharanta S, Zuber J
Cancer discovery – 2024 Jan 12
Whole-genome doubling drives oncogenic loss of chromatin segregation.
Lambuta RA, Nanni L, Liu Y, (...), Katanayeva N, Ciriello G, Oricchio E
Nature – 2023 Mar 15
Epistasis and evolutionary dependencies in human cancers.
Mina M, Iyer A, Ciriello G
Current opinion in genetics & development – 2022 Sep 28
Frequent 4EBP1 Amplification Induces Synthetic Dependence on FGFR Signaling in Cancer.
Mohan P, Pasion J, Ciriello G, (...), Wendel HG, Sanghvi VR, Singh K
Cancers – 2022 May 13
Team
Giovanni Ciriello
Principal Investigator, Computational Biology & Cancer Genomics group, UNIL
CiriellolabSelected Publications
Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL.
Antoszewski M, Fournier N, Ruiz Buendía GA, (...), Weng AP, Koch U, Radtke F
Blood – 2022 Apr 21
Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING.
Bruand M, Barras D, Mina M, (...), Martinon F, Dangaj Laniti D, Coukos G
Cell reports – 2021 Jul 20
The many faces of cancer evolution.
Ciriello G, Magnani L
iScience – 2021 May 11
Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes.
Liu Y, Nanni L, Sungalee S, (...), Ceri S, Oricchio E, Ciriello G
Nature communications – 2021 May 10
Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci.
Sungalee S, Liu Y, Lambuta RA, (...), Roulland S, Ciriello G, Oricchio E
Nature genetics – 2021 May 10
Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression.
Saghafinia S, Homicsko K, Di Domenico A, (...), Ciriello G, Michael IP, Hanahan D
Cancer discovery – 2021 Apr 28
Discovering functional evolutionary dependencies in human cancers.
Mina M, Iyer A, Tavernari D, Raynaud F, Ciriello G
Nature genetics – 2020 Sep 28
Dynamic Emergence of Observed and Hidden Intra-tumor Heterogeneity.
Raynaud F, Mina M, Ciriello G
iScience – 2019 Oct 10
EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains.
Donaldson-Collier MC, Sungalee S, Zufferey M, (...), Manley S, Ciriello G, Oricchio E
Nature genetics – 2019 Jan 28
Comparison of computational methods for the identification of topologically associating domains.
Zufferey M, Tavernari D, Oricchio E, Ciriello G
Genome biology – 2018 Dec 10
Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors.
Saghafinia S, Mina M, Riggi N, Hanahan D, Ciriello G
Cell reports – 2018 Oct 23
Pan-cancer inference of intra-tumor heterogeneity reveals associations with different forms of genomic instability.
Raynaud F, Mina M, Tavernari D, Ciriello G
PLoS genetics – 2018 Sep 13
Oncogenic Signaling Pathways in The Cancer Genome Atlas.
Sanchez-Vega F, Mina M, Armenia J, (...), Ciriello G, Sander C, Schultz N
Cell – 2018 Apr 5
Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies.
Mina M, Raynaud F, Tavernari D, (...), Schultz N, Oricchio E, Ciriello G
Cancer cell – 2017 Jul 27
Emerging landscape of oncogenic signatures across human cancers.
Ciriello G, Miller ML, Aksoy BA, (...), Senbabaoglu Y, Schultz N, Sander C
Nature genetics – 2013 Oct
Related news
Events
ISREC-SCCL Symposium 2025 | September 1–4
Events
AGORA Sustainability Day
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Lola and John Grace Distinguished Lecture in Cancer Research, Prof. Jean-Christophe Marine | March 21st
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AGORA PRS | March 12th
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Lola and John Grace Distinguished Lecture in Cancer Research, Dr. Eliezer Van Allen | December 7th
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Lola and John Grace Distinguished Lecture in Cancer Research, Prof. Dana Pe’er | November 2nd
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