Harari lab
We aim to understand T-cells dynamic and correlates of efficacy in cancer patients treated with experimental immunotherapies and to develop analytical tools and pipelines for applications in immune discovery and in the development of novel strategies of cellular therapies ...
Research projects
Please check back later to discover our ongoing projects.
Latest publications
Personalized cancer T-cell therapy takes the stage, mirroring vaccine success.
Chiffelle J, Harari A
The Journal of experimental medicine – 2024 Jun 11
Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms.
Pétremand R, Chiffelle J, Bobisse S, (...), Coukos G, Zoete V, Harari A
Nat Biotechnol – 2024 May 7
PGE(2) inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function.
Morotti M, Grimm AJ, Hope HC, (...), Böttcher JP, Dangaj Laniti D, Coukos G
Nature – 2024 Apr 24
Deep learning predictions of TCR-epitope interactions reveal epitope-specific chains in dual alpha T cells.
Croce G, Bobisse S, Moreno DL, (...), Guillame P, Harari A, Gfeller D
Nature communications – 2024 Apr 13
Response to tumor-infiltrating lymphocyte adoptive therapy is associated with preexisting CD8(+) T-myeloid cell networks in melanoma.
Barras D, Ghisoni E, Chiffelle J, (...), Harari A, Laniti DD, Coukos G
Science immunology – 2024 Feb 2
Intradermal skin test with mRNA vaccines as a surrogate marker of T cell immunity in immunocompromised patients.
Fallet B, Foglierini M, Porret R, (...), Gottardo R, Pantaleo G, Muller YD
The Journal of infection – 2023 Jun 14
Team
Other members
Selected Publications
Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes.
Racle J, Guillaume P, Schmidt J, (...), Bassani-Sternberg M, Harari A, Gfeller D
Immunity – 2023 Mar 30
Improved predictions of antigen presentation and TCR recognition with MixMHCpred2.2 and PRIME2.0 reveal potent SARS-CoV-2 CD8(+) T-cell epitopes.
Gfeller D, Schmidt J, Croce G, (...), Cesbron J, Racle J, Harari A
Cell systems – 2023 Jan 4
Vaccines as Priming Tools for T Cell Therapy for Epithelial Cancers.
Kandalaft LE, Harari A
Cancers – 2021 Nov 19
Sensitive identification of neoantigens and cognate TCRs in human solid tumors.
Arnaud M, Chiffelle J, Genolet R, (...), Bobisse S, Coukos G, Harari A
Nature biotechnology – 2021 Nov 15
The Promise of Personalized TCR-Based Cellular Immunotherapy for Cancer Patients.
Arnaud M, Bobisse S, Chiffelle J, Harari A
Frontiers in immunology – 2021 Jul 30
Unsupervised Analysis of Flow Cytometry Data in a Clinical Setting Captures Cell Diversity and Allows Population Discovery.
Baumgaertner P, Sankar M, Herrera F, (...), Xenarios I, Guex N, Harari A
Frontiers in immunology – 2021 Apr 30
Personalized cancer vaccine strategy elicits polyfunctional T cells and demonstrates clinical benefits in ovarian cancer.
Tanyi JL, Chiang CL, Chiffelle J, (...), Coukos G, Harari A, Kandalaft LE
NPJ vaccines – 2021 Mar 15
T-cell repertoire analysis and metrics of diversity and clonality.
Chiffelle J, Genolet R, Perez MA, (...), Coukos G, Zoete V, Harari A
Current opinion in biotechnology – 2020 Sep 2
Structural dissimilarity from self drives neoepitope escape from immune tolerance.
Devlin JR, Alonso JA, Ayres CM, (...), Gfeller D, Harari A, Baker BM
Nature chemical biology – 2020 Aug 17
Antitumour dendritic cell vaccination in a priming and boosting approach.
Harari A, Graciotti M, Bassani-Sternberg M, Kandalaft LE
Nature reviews. Drug discovery – 2020 Aug 6
Biotechnologies to tackle the challenge of neoantigen identification.
Arnaud M, Duchamp M, Bobisse S, (...), Renaud P, Coukos G, Harari A
Current opinion in biotechnology – 2020 Jan 8
Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes.
Racle J, Michaux J, Rockinger GA, (...), Jandus C, Bassani-Sternberg M, Gfeller D
Nature biotechnology – 2019 Oct 14
Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells.
Mastelic-Gavillet B, Navarro Rodrigo B, Décombaz L, (...), Romero P, Harari A, Vigano S
Journal for immunotherapy of cancer – 2019 Oct 10
Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer.
Tanyi JL, Bobisse S, Ophir E, (...), Harari A, Coukos G, Kandalaft LE
Science translational medicine – 2018 Apr 11
Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer.
Bobisse S, Genolet R, Roberti A, (...), Kandalaft LE, Coukos G, Harari A
Nature communications – 2018 Mar 15
Dominant TNF-α+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease.
Harari A, Rozot V, Bellutti Enders F, (...), Hanekom WA, Bart PA, Pantaleo G
Nature medicine – 2011 Feb 20
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