In Vivo Imaging Facility – IVIF
The In Vivo Imaging Facility (IVIF) offers state-of-the-art, non-invasive, multimodal in vivo imaging services for the study of preclinical pathological models in live animals. The platform is directly integrated into the AIVC in the same controlled sanitary space, which allows the mice to be housed for the duration of their follow-up under optimum sanitary and regulatory conditions, as well as satisfying “Reduce” and “Refine” of the “3Rs” rule for animal experimentation.
Mission
The IVIF Platform has several missions and services:
- Training of researchers in the use of the equipment.
- Expertise for the development of new imaging protocols.
- Assistance in the acquisition and analysis of images.
- Ensuring maintenance and quality control of the equipment.
- Ensuring the safety of users as experts in radioprotection.
- Organization of seminars to inform users about different state-of-the-art technologies.
- Ensure communication to researchers (website, booking systems).
- Scientific monitoring and development.
Resources
The IVIF equipment:
- Two bioluminescence/fluorescence imaging systems (IVIS type), in zones BSL1 and BSL2.
- A 3-Tesla MRI (magnetic resonance imaging) equipped with a cryoprobe.
- A micro CT (micro computed tomography).
- A focused irradiator with collimators and planning software for radiotherapy.
- A global irradiator for bone marrow transplantation.
- A PET/CT scan machine for imaging of radiolabelled elements.
- Two multi-photon microscopes for dynamic intra-vital imaging.
- An ultrasound scanner.
Selected Publications
Macrophage migration inhibitory factor blockade reprograms macrophages and disrupts prosurvival signaling in acute myeloid leukemia.
Spertini C, Bénéchet AP, Birch F, (…), Mitchell RA, Spertini O, Smirnova T
Cell death discovery – 2024 Mar 28
Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms
Bejarano L, Kauzlaric A, Lamprou E, (…), Daniel RT, Hegi ME, Joyce JA
Cancer Cell – 2024 Jan 18
