Joyce lab
Our research program is focused on understanding how reciprocal communication between cancer cells and diverse immune and stromal cell types in the tumor microenvironment (TME) controls tumor initiation, progression, and metastasis, and modulates the response to therapeutic intervention. We employ a broad range of complementary experimental strategies to deeply interrogate the TME including the comprehensive analysis of patient samples (RNA-seq, proteomics, immune phenotyping, single cell analyses etc), mouse models of cancer, multi-modal in vivo imaging platforms, co-culture systems to mimic the TME, and diverse computational analyses. ...
Research projects
Tumor microenvironment
We currently have multiple projects focused on exploring the TME of primary and metastatic brain cancers, including analyses of diverse immune cell phenotypes, the blood and lymphatic vascular networks, and interrogation of the unique properties of the brain extracellular matrix. We are also fascinated by the dynamic evolution of the TME during cancer progression and metastasis in several tumor types, including breast, melanoma and lung cancer. Another major area of interest focuses on how different therapies alter the TME, and how those changes can consequently modulate therapeutic outcome. Our ultimate goal is to apply all of this knowledge to the clinic and develop targeted therapies that disrupt essential tumor-microenvironment interactions for the benefit of patients.
Latest publications
Fibrotic response to anti-CSF-1R therapy potentiates glioblastoma recurrence.
Watson SS, Zomer A, Fournier N, (...), Cossu G, Hottinger AF, Joyce JA
Cancer Cell – 2024 Sep 9
Investigation of a fluorescent reporter microenvironment niche labeling strategy in experimental brain metastasis
Massara M, Dolfi B, Wischnewski V, (...), Held W, Malanchi I, Joyce JA
iScience – 2024 Jul 19
Microenvironmental reorganization in brain tumors following radiotherapy and recurrence revealed by hyperplexed immunofluorescence imaging
Watson SS, Duc B, Kang Z, (...), Bodenmiller B, Hausser J, Joyce JA
Nature Communications – 2024 Apr 15
Embracing cancer complexity: Hallmarks of systemic disease.
Swanton C, Bernard E, Abbosh C, (...), Wood JN, Vousden KH, Hanahan D
Cell – 2024 Mar 28
Closing the scissor-shaped curve: Strategies to promote gender equality in academia.
Joyce JA, Masina S, Michalik L, (...), Pot C, Sempoux C, Amati F
Cell – 2024 Mar 14
Team
Johanna Joyce
Full Professor, Laboratory of Tumor microenvironment, Department of Oncology UNIL & CHUV, Full Member Ludwig Institute for Cancer Research Lausanne Branch
JoyceLabOther members
Selected Publications
Fibrotic response to anti-CSF-1R therapy potentiates glioblastoma recurrence.
Watson SS, Zomer A, Fournier N, (...), Cossu G, Hottinger AF, Joyce JA
Cancer Cell – 2024 Sep 9
Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms
Bejarano L, Kauzlaric A, Lamprou E, (...), Daniel RT, Hegi ME, Joyce JA
Cancer Cell – 2024 Jan 18
The local microenvironment drives activation of neutrophils in human brain tumors.
Maas RR, Soukup K, Fournier N, (...), Roy DT, Hegi ME, Joyce JA
Cell – 2023 Sep 27
Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation
Wischnewski V, Maas RR, Guerrero Aruffo P, (...), Hegi ME, Lugli E, Joyce JA
Nature Cancer – 2023 May 22
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
de Visser KE, Joyce JA
Cancer Cell – 2023 Mar 13
Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors.
Álvarez-Prado ÁF, Maas RR, Soukup K, (...), Daniel RT, Hegi ME, Joyce JA
Cell Reports Medicine – 2023 Jan 17
Multispectral fluorine-19 MRI enables longitudinal and noninvasive monitoring of tumor-associated macrophages
Croci D, Santalla Méndez R, Temme S, (...), Flögel U, van Heeswijk RB, Joyce JA
Science Translational Medicine – 2022 Oct 19
Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis.
Klemm F, Möckl A, Salamero-Boix A, (...), Plate KH, Joyce JA, Sevenich L
Nature cancer – 2021 Oct 18
An integrated pipeline for comprehensive analysis of immune cells in human brain tumor clinical samples.
Maas RR, Soukup K, Klemm F, (...), Daniel RT, Hegi ME, Joyce JA
Nature protocols – 2021 Aug 30
Therapeutic Targeting of the Tumor Microenvironment.
Bejarano L, Jordāo MJC, Joyce JA
Cancer discovery – 2021 Apr
Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance.
Akkari L, Bowman RL, Tessier J, (...), Westerga J, Watts C, Joyce JA
Science translational medicine – 2020 Jul 15
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells.
Klemm F, Maas RR, Bowman RL, (...), Daniel RT, Hegi ME, Joyce JA
Cell – 2020 May 28
Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF.
Quail DF, Olson OC, Bhardwaj P, (...), Holt PR, Dannenberg AJ, Joyce JA
Nature cell biology – 2017 Jul 24
Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents.
Olson OC, Kim H, Quail DF, Foley EA, Joyce JA
Cell reports – 2017 Apr 4
The Microenvironmental Landscape of Brain Tumors.
Quail DF, Joyce JA
Cancer cell – 2017 Mar 13
Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies.
Bowman RL, Klemm F, Akkari L, (...), Tabar V, Gutin PH, Joyce JA
Cell reports – 2016 Nov 10
STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation.
Yan D, Wang HW, Bowman RL, Joyce JA
Cell reports – 2016 Sep 13
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas.
Quail DF, Bowman RL, Akkari L, (...), Holland EC, Sutton JC, Joyce JA
Science (New York, N.Y.) – 2016 May 20
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.
Akkari L, Gocheva V, Quick ML, (...), Garfall AL, Bowman RL, Joyce JA
Genes & development – 2016 Jan 15
T cell exclusion, immune privilege, and the tumor microenvironment.
Joyce JA, Fearon DT
Science (New York, N.Y.) – 2015 Apr 3
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.
Sevenich L, Bowman RL, Mason SD, (...), Massagué J, Leslie CS, Joyce JA
Nature cell biology – 2014 Aug 3
CSF-1R inhibition alters macrophage polarization and blocks glioma progression.
Pyonteck SM, Akkari L, Schuhmacher AJ, (...), Holland EC, Daniel D, Joyce JA
Nature medicine – 2013 Sep 22
Related news
Events
AGORA Tumor Microenvironment Journal Club | December 13th
Events
LabLinks: Tumor immunology and immunotherapy | November 11&12th
Events
AGORA Sustainability Day
Events
Ludwig Distinguished Lecture, Prof. Jacco van Rheenen | June 20th
Events
“Women in Science Now” event | June 24
Events
AGORA PRS | April 30th
Events
AGORA PRS | April 23rd
Events
AGORA PRS | April 16th
Events
EACR ‘Meet the Expert Webinar’ with Prof. Johanna Joyce | December 7th
Events
AGORA PRS – Special seminar | September 19th
Events
ISREC-SCCL Symposium 2023 | August 21-24
Events
AGORA PRS | June 20th
Events
Women in Science: Perspectives from Ludwig leaders | March 8th
Events
AGORA PRS | March 14th
Events
AGORA Workshop – Spatial Multi-Omics: Use in Biology and Medicine | January 18th
Events
